Brain Training: Computer Games for Improved Cognition

The purpose of this trial is to identify whether playing computer games improves cognition, including memory and attention, in young people at high risk for developing a psychotic disorder. The study involves an initial screening, after which potential participants are invited to the lab for a clinical interview to further determine eligibility. Eligible participants will be enrolled in an internet-based cognitive training program that will require participants to complete several computer games each day for four to five weeks at a time. Participants will also complete questionnaires, behavioral tasks, a MRI, and a daily diary at the beginning, middle, and end of the internet-based training. The majority of the study will last 10-12 weeks; however, participants will be asked to return for a nine-month follow-up visit to complete additional questionnaires and behavioral tasks. Participants will be compensated up to $2,000 for their time and effort.

Who is eligible?

In order to participate you must meet the following criteria:

  • Be between 15 and 30 years old at the time of study screening.
  • Have mild psychotic-like symptoms, such as odd perceptual experiences, subtle auditory or visual hallucinations, feeling that your mind is playing tricks on you.
  •  You may also be eligible if you have a first degree relative with a psychotic disorder.

You will be excluded from the study if any of the following criteria apply to you:

  • Have met criteria for a psychotic disorder (including schizoaffective disorder schizophrenia)
  • Have major medical illness or neurological disorder.

This is a partial list of eligibility requirements. To inquire about your eligibility, please call the contact number provided. If you wish to inquire via email, please include the title of the study in your message.

What's involved?  

  • Three assessment sessions; pre-, mid-, and post- training
  • Completion of a daily diary for seven days
  • Three fMRI scans at Rush
  • 40 sessions of computer game play which is completed at home
  • A 9 month follow-up 
Interested in this study? Contact us at rushbraintrain@gmail.com or call us at (312) 502-2501.

 

Improving Social Cognition in Schizophrenia

The purpose of this trial is to study the efficacy of an internet-based targeted cognitive treatment meant to improve social cognition in people with schizophrenia. The study involves an initial phone screening after which potential participants are invited to the lab for a clinical interview to further determine eligibility. Eligible participants will be enrolled in an internet-based treatment that requires participants to complete several games each day for several weeks. Participants will also complete questionnaires, behavioral tasks and a MRI at the beginning, middle, and end of the study at the lab. Participation is expected to last 10-12 weeks and will be compensated up to $600 for their time and effort.

Who is eligible?  
This study is recruiting individuals who meet the diagnosis for schizophrenia or schizoaffective disorder.
In order to participate you must:

  • be between 18 and 65 years old 
  • have no psychiatric hospitalizations for at least 8 weeks prior to enrollment
  • have no changes to your psychiatric medications for at least 6 weeks prior to enrollment

You will be excluded from the study if you:  

  • have a major medical illness or neurological disorder

What's involved?  

  • An initial 2 hour interview
  • Three assessment sessions: pre-, mid-, and post- training
  • Two fMRI scans at Rush 
  • 40 sessions of computer game play done at home
Interested in this study? Contact us at rushsocialbrain@gmail.com or call (312) 502-2501.

Bipolar Remediation of Affective Control and Emotional Stability Study

The purpose of this study is to determine whether cognitive control of emotion can be enhanced in young adults with recent on-set Bipolar I Disorder using an internet-based targeted cognitive training program. The study will last approximately six weeks with the majority of the study being completed at home. Participants will be compensated approximately $600 for completion of the study.

Who is eligible?

The study is recruiting individuals who meet for the diagnosis of Bipolar I Disorder. In order to participate, you must:

  • Be between the ages of 18 and 30 years old
  • Have had onset of bipolar disorder in the last five years
  • Have not had a psychiatric hospitalization in the 6 weeks prior to enrollment
  • Have not had a change in psychiatric medication in the 6 weeks prior to enrollment

You will be excluded from the study if you:

  • Have a major medical illness or neurological disorder, including a traumatic brain injury or seizures 
  • If you have any medical issues or MRI-incompatible implants that would prevent you from receiving a MRI

What’s involved?

  • Two assessment sessions involving a personal interview, questionnaires, and computer-tasks testing memory, attention, and reasoning and problem solving at Rush University Medical Center
  • Two functional MRI scans at Northwestern’s downtown Center for Translational Imaging
  • 20 hours of online-based cognitive training that consists of playing games on an iOS device

Funding: This work is being funded by the Ryan Licht Sang Bipolar Foundation.